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Tight function zonula occludens-3 regulates cyclin D1–dependent cell proliferation

By Christopher T. Capaldo, Stefan Koch, Michael Kwon, Oskar Laur, Charles A. Parkos and Asma Nusrat


We show here that zonula occludens (ZO)-3 acts to sequester cyclin D1 at intercellular tight junctions. This study highlights an important new role for ZO family proteins in regulating epithelial cell proliferation through stabilization of cyclin D1 during mitosis

Topics: Articles
Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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