Article thumbnail

Esophageal Small Cell Carcinoma with Synchronous Renal Cell Carcinoma: A Case Report with Review of the Literature

By Parakkal Deepak, Radha Devi and Harikrishnan Pillai

Abstract

Synchronous malignancies with an esophageal malignancy are not uncommon. However synchronous esophageal and renal cell carcinoma (RCC) is rare with only 11 cases reported in the world literature, the esophageal malignancies being adenocarcinomas or squamous cell carcinomas. Here, we report the first case of synchronous small cell carcinoma (SCC) of the esophagus with a RCC. SCC of the esophagus is an aggressive malignancy with poor prognosis constituting 0.8–2.4% of all esophageal malignancies, currently treated with induction chemotherapy followed by chemoradiotherapy. Our patient underwent chemoradiotherapy for the SCC of the esophagus followed by radical nephrectomy for the RCC. He developed metastatic disease and died 8 months after diagnosis. Larger case series are required to develop a treatment algorithm for such a rare presentation. The key points of this report are: (1) Synchronous RCC with a primary esophageal carcinoma is a rare presentation. (2) This is the first described case report of a SCC of the esophagus with a synchronous RCC. (3) Overall prognosis in a synchronous presentation is determined by the primary esophageal malignancy. (4) Esophageal carcinomas with synchronous malignancies have a poorer prognosis compared to isolated esophageal carcinoma

Topics: Published: April 2011
Publisher: S. Karger AG
OAI identifier: oai:pubmedcentral.nih.gov:3088748
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1991). A case of double primary malignant neoplasm in the esophagus and kidney. Shokaki Naishikyo No Shinpo
  2. (2009). al: Clinical analysis of 126 patients with primary small cell carcinoma of the esophagus (in Chinese). Zhonghua Zhong Liu Za Zhi
  3. (2001). al: Multiple primary cancers associated with esophageal carcinoma. Surg Today
  4. et al: Synchronous esophageal and renal cell carcinoma. Dis Esophagus
  5. (2008). Ilson DH: Small cell carcinoma of the esophagus and gastroesophageal junction: review of the Memorial Sloan-Kettering experience. Ann Oncol
  6. (2008). Lanschot JJ: Synchronous esophageal and renal cell carcinoma: incidence and possible treatment strategies. Dig Surg
  7. (1997). RV: Extrapulmonary small cell carcinoma. Cancer
  8. Simultaneously renal cell carcinoma, adrenal adenoma, and carcinoma of the esophagus: report of a case.