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Trioxaquine PA1259 Alkylates Heme in the Blood-Feeding Parasite Schistosoma mansoni▿

By Vincent Pradines, Julien Portela, Jérôme Boissier, Frédéric Coslédan, Bernard Meunier and Anne Robert


Trioxaquine PA1259 is an efficient drug on larval- and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites

Topics: Mechanisms of Action: Physiological Effects
Publisher: American Society for Microbiology
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Provided by: PubMed Central
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