Location of Repository

Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma

By H. Al-Hussaini, D. Hogg, M. E. Blackstein, B. O'Sullivan, C. N. Catton, P. W. Chung, A. M. Griffin, D. Hodgson, S. Hopyan, R. Kandel, P. C. Ferguson, J. S. Wunder and A. A. Gupta

Abstract

Background. There remains controversy on the routine use of chemotherapy in localized SS. Methods. The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed. Results. Median age for AP and PP was 37.6 (range 15–76) and 14 (range 0.4–18) years, respectively. 65 (64%) patients had large tumours (>5 cm). All patients underwent en bloc surgical resection resulting in 94 (92.2%) negative and 8 (7.8%) microscopically positive surgical margins. 72 (82.8%) AP and 8 (53%) PP received radiotherapy. Chemotherapy was administered to 12 (13.8%) AP and 13 (87%) PP. 10 AP and 5 PP were evaluable for response to neoadjuvant chemotherapy, with response rate of 10% and 40%, respectively. 5-year EFS and OS was 69.3 ± 4.8% and 80.3 ± 4.3%, respectively, and was similar for AP and PP, In patients with tumors >5 cm, in whom chemotherapy might be considered most appropriate, relapse occurred in 9/19 (47%) with chemotherapy, compared to 17/46 (37%) In those without. Conclusions. Patients with localized SS have a good chance of cure with surgery and RT. Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:3087894
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2008). A .L eC e s n e ,M .V a nG l a b b e k e ,P .J .W o l le ta l . ,“ T h e end of adjuvant chemotherapy era with doxorubicin-based regimen in resected high-grade soft tissue sarcoma(STS): pooled analysis of the two STBSG-EORTC phase III clinical trials,”
    2. (1994). A .S .P a p p o ,J .F o n t a n e s i ,X .L u oe ta l . ,“ S y n o v i a ls a r c o m a in children and adolescents: the St Jude Children’s research hospital experience,”
    3. (2001). A n d r a s s y ,M .F .O k c u ,S .D e s p a ,a n dR .B .R a n e y , “Synovial sarcoma in children: surgical lessons from a single institution and review of the literature,”
    4. (1996). A note on quantifying followup in studies of failuretime,”
    5. (1980). A system for the surgical staging of musculoskeletal sarcoma,”
    6. (2009). Alberghini et al., “Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution,”
    7. (2008). C a n t e r ,L .X .Q i n ,R .G .M a k i ,M .F .B r e n n a n ,M .L a d a n y i
    8. (2007). Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma,”
    9. (2006). Grossly-resected synovial sarcoma treated by the German and Italian pediatric soft tissue sarcoma cooperative groups: discussion on the role of adjuvant therapies,”
    10. (1977). H a j d u ,M .H .S h i u ,a n dJ .G .F o r t n e r ,“ T e n d o s y n o v i a l sarcoma.Aclinicopathologicalstudyof136cases,”Cancer,v ol.
    11. (2001). Hac` ene et al., “Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients,”
    12. (2004). Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis,”JournalofClinicalOncology,vol.22,no. 20,
    13. (1996). i n g e r ,E .H .B a l d i n i ,G .D .D e m e t r i ,J .A .F l e t c h e r ,a n dJ .M . Corson, “Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival,”6
    14. (2009). i s e n h a u e r ,P .T h e r a s s e ,J .B o g a e r t se ta l . ,“ N e wr e s p o n s e evaluationcriteria in solidtumours:revised RECIST guideline (version 1.1),”
    15. (2007). Longterm outcomes forsynovial sarcomatreated with conservation surgery and radiotherapy,”
    16. (2009). Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group,”
    17. (2009). Palmerini,L.Zanellaet al.,“Synovialsarcoma:retrospective analysis of 250 patients treated at a single institution,”
    18. (2001). Prognostic significance of histologic grade and nuclear expression of β-catenin in synovial sarcoma,”
    19. (2003). r u s t a c i ,A .D eP a o l i ,E .B i d o l ie ta l . ,“ I f o s f a m i d ei nt h e adjuvant therapy of soft tissue sarcomas,”
    20. (2001). r u s t a c i ,F .G h e r l i n z o n i ,A .D eP a o l ie ta l . ,“ A d j u v a n t chemotherapy for adult soft tissue sarcomas of the extremities andgirdles:resultsoftheitalianrandomizedcooperativetrial,”
    21. (2001). S.G.J.Weiss,“Malignantsofttissuetumorsofuncertaintype,” in Enzinger and Weiss’s Soft Tissue Tumors,S .W .W e i sa n dJ
    22. (1993). Synovial sarcoma of childhood and adolescence:
    23. (2000). Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity,”
    24. (1999). Synovial sarcoma: report of a series of 25 consecutive children from a singleinstitution,”Medical and Pediatric Oncology,
    25. (2003). Treuner et al., “Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome,”

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.