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The structure of the PERK kinase domain suggests the mechanism for its activation

By Wenjun Cui, Jingzhi Li, David Ron and Bingdong Sha

Abstract

The endoplasmic reticulum-localized transmembrane kinase PERK is one of three major ER stress transducers. The crystal structure of PERK’s kinase domain has been determined to 2.8 Å resolution

Topics: Research Papers
Publisher: International Union of Crystallography
OAI identifier: oai:pubmedcentral.nih.gov:3087621
Provided by: PubMed Central
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