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Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography: Comparison of Normal Pregnancy and Intrauterine Growth Restriction

By Akimune Fukushima, Kenji Nakai, Tomonobu Kanasugi, Miyuki Terata and Toru Sugiyama


Objective. To clarify the developmental activity of the autonomic nervous system (ANS) of the normal fetus and intrauterine growth restriction (IUGR) cases using fetal magnetocardiography (FMCG). Subjects and Methods. Normal pregnancy (n = 35) and IUGR (n = 12) cases at 28–39 and 32–37 weeks of gestation, respectively, were included in this study. The R-R interval variability was used to calculate the coefficient of variance (CVRR) and low frequency/high frequency (LF/HF) ratio. Results. The value of CVRR in the normal pregnancy group displayed a slight increasing trend with gestational age. However, no such trend was observed in the IUGR group. In contrast, the LF/HF ratio in both the normal pregnancy group and the IUGR group clearly increased over the gestational period; the normal group showing statistical significance. Conclusion. The development of fetal ANS activity in IUGR cases might differ from that observed in the normal pregnancy group, and this may facilitate early detection of IUGR

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:3087145
Provided by: PubMed Central
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    1. (2001). A fetal Wolff-Parkinson-White syndrome diagnosed prenatally by magnetocardiography,” Fetal Diagnosis and Therapy,
    2. (1999). a nL e e u w e n ,B .H a i l e r ,W .B a d e r ,J .G e i s s l e r ,E .T o w i t z s c h
    3. (1995). a s s ia n dM .J .L e w i s ,“ P o w e rs p e c t r a la n a l y s i so ft h ef o e t a l magnetocardiogram,”
    4. (1986). An efficient algorithm for spectral analysis of heart rate variability,”
    5. (2000). Assessment of fetal rhythm in complete congenital heart block by magnetocardiography,”
    6. (1996). B i g g e r ,R .C .S t e i n m a n ,L .M .R o l n i t z k y ,J .L .F l e i s s
    7. (2008). Cerebral palsy and restricted growth status at birth,”
    8. (2006). Cerebral palsy in a term population: risk factors and neuroimaging findings,”
    9. (2003). Chaotic and periodic analysis of fetal magnetocardiogram recordings in growth restriction,”
    10. (1989). Concurrence of mouthing movement and rapid eye movement/non-rapid eye movement phases with advance in gestation of the human fetus,”
    11. (1998). Fetal growth restriction at term: myth or reality?”
    12. (2000). Fetal supraventricular tachycardias: diagnosis and management,”Seminars
    13. (1999). H.Hamada,H.Horigome,M.Asakaet al.,“Prenataldiagnosis of long QT syndrome using fetal magnetocardiography,”
    14. (2003). Influence of intrauterine growth restriction on cardiac time intervals evaluated by fetal magnetocardiography,” Early Human Development,
    15. (1995). Intrauterine growth retardation,” in Fetal Medicine. Principles and Practice,
    16. (2008). Itoh et al., “Assessment of fetal autonomic nervous system activity by fetal magnetocardiography,”
    17. (2005). Izumoto et al., “Construction of a three-dimensional outline of the heart and conduction pathway by means of a 64-channel magnetocardiogram in patients with atrial flutter and fibrillation,”
    18. (1981). k s e l r o d ,D .G o r d o n ,a n dF .A .U b e l ,“ P o w e rs p e c t r u m analysis of heart rate fluctuation: a quantitative probe of beatto-beat cardiovascular control,”Science,vol.213,no.4504,
    19. (2008). l a t za n dR .N e w m a n ,“ D i a g n o s i so fI U G R :t r a d i t i o n a l biometry,” Seminars in Perinatology,
    20. (1994). l b e r t ,W .J .R a y ,Z .J .K o w a l i k ,J .E .S k i n n e r ,K .E .G r a f ,a n d N. Birbaumer, “Chaos and physiology: deterministic chaos in excitable cell assemblies,”
    21. (2001). Linear analysis of fetal magnetocardiogram recordings in normal pregnancies at various
    22. (1999). M c i n t i r e ,S .L .B l o o m ,B .M .C a s e y ,a n dK .J .L e v e n o , “Birth weight in relation to morbidity and mortality among newborn infants,” The New England
    23. (2000). Magnetocardiographic determination of the developmental changes
    24. (1996). N e l s o n ,J .M .D a m b r o s i a ,T .Y .T i n g ,a n dJ .K .G r e t h e r , “Uncertain value of electronic fetal monitoring in predicting cerebral palsy,” The New England
    25. (1988). Perinatal antecedents of cerebral palsy,”
    26. (2001). The application of fetal magnetocardiography (FMCG) to investigate fetal arrhythmias and congenital heart defects
    27. (2006). Three-dimensional recovery time dispersion map by 64-channel magnetocardiography may demonstrate the location of a myocardial injury and heterogeneity of repolarization,”
    28. (1967). Trends in perinatal mortality and cerebral palsy in
    29. (2002). Tsukada,“PrenataldiagnosisoflongQTsyndromeusingmagnetocardiography: a case report and review of the literature,”
    30. (2001). Usefulness of magnetocardiography for the investigation of fetal arrhythmias,”
    31. (2003). W a k a i ,J .F .S t r a s b u r g e r

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