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The Role of Matrix Metalloproteinase-9 in Cigarette Smoke–induced Emphysema

By Jeffrey J. Atkinson, Barbara A. Lutey, Yoko Suzuki, Holly M. Toennies, Diane G. Kelley, Dale K. Kobayashi, Whitney G. Ijem, Gaetan Deslee, Carla H. Moore, M. Eileen Jacobs, Susan H. Conradi, David S. Gierada, Richard A. Pierce, Tomoko Betsuyaku and Robert M. Senior

Abstract

Rationale: Matrix metalloprotease (MMP)-9 is an elastolytic endopeptidase produced by activated macrophages that may be involved in the development of human pulmonary emphysema and could be inhibited with existing compounds. Mouse models have demonstrated that excess MMP-9 production can result in permanent alveolar destruction

Topics: B. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:3086754
Provided by: PubMed Central
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