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Segmental Allergen Challenge Alters Multimeric Structure and Function of Surfactant Protein D in Humans

By Elena N. Atochina-Vasserman, Carla Winkler, Helen Abramova, Frank Schaumann, Norbert Krug, Andrew J. Gow, Michael F. Beers and Jens M. Hohlfeld

Abstract

Rationale: Surfactant protein D (SP-D), a 43-kD collectin, is synthesized and secreted by airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have previously shown that the quaternary structure of SP-D can be altered during inflammatory lung injury through its modification by S-nitrosylation, which in turn alters its functional behavior producing a proinflammatory response in effector cells

Topics: A. Asthma and Allergy
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:3086753
Provided by: PubMed Central
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