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A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome: Reversal by Macrophage Depletion

By Thenappan Thenappan, Ankush Goel, Glenn Marsboom, Yong-Hu Fang, Peter T. Toth, Hannah J. Zhang, Hidemi Kajimoto, Zhigang Hong, Jonathan Paul, Christian Wietholt, Jennifer Pogoriler, Lin Piao, Jalees Rehman and Stephen L. Archer

Abstract

Rationale: The etiology of hepatopulmonary syndrome (HPS), a common complication of cirrhosis, is unknown. Inflammation and macrophage accumulation occur in HPS; however, their importance is unclear. Common bile duct ligation (CBDL) creates an accepted model of HPS, allowing us to investigate the cause of HPS

Topics: F. Pulmonary Vascular Disease
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:3086745
Provided by: PubMed Central
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