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Tunable Plasmonic Nanoprobes for Theranostics of Prostate Cancer

By Ekaterina Y. Lukianova-Hleb, Alexander O. Oginsky, Adam P. Samaniego, Derek L. Shenefelt, Daniel S. Wagner, Jason H. Hafner, Mary C. Farach-Carson and Dmitri O. Lapotko

Abstract

Theranostic applications require coupling of diagnosis and therapy, a high degree of specificity and adaptability to delivery methods compatible with clinical practice. The tunable physical and biological effects of selective targeting and activation of plasmonic nanobubbles (PNB) were studied in a heterogeneous biological microenvironment of prostate cancer and stromal cells. All cells were targeted with conjugates of gold nanoparticles (NPs) through an antibody-receptor-endocytosis-nanocluster mechanism that produced NP clusters. The simultaneous pulsed optical activation of intracellular NP clusters at several wavelengths resulted in higher optical contrast and therapeutic selectivity of PNBs compared with those of gold NPs alone. The developed mechanism was termed “rainbow plasmonic nanobubbles.” The cellular effect of rainbow PNBs was tuned in situ in target cells, thus supporting a theranostic algorithm of prostate cancer cell detection and follow-up guided destruction without damage to collateral cells. The specificity and tunability of PNBs is promising for theranostic applications and we discuss a fiber optic platform that will capitalize on these features to bring theranostic tools to the clinic

Topics: Research Paper
Publisher: Ivyspring International Publisher
OAI identifier: oai:pubmedcentral.nih.gov:3086615
Provided by: PubMed Central

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Citations

  1. (2010). A molecularly targeted theranostic probe for ovarian cancer. Mol Cancer Ther
  2. Applications of gold nanorods for cancer imaging and photothermal therapy. Methods Mol Biol.
  3. (2010). Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice.
  4. (2009). Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres.
  5. (1989). Clinical use of laser-tissue interactions.
  6. (2007). Clusterization of nanoparticles during their interaction with living cells. Nanomedicine
  7. (2004). Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines.
  8. (2010). contrast enhanced photoacoustic imaging of cancer in a mouse window chamber. Optics Express
  9. (1989). Dosimetry for laser induced hyperthermia.
  10. (2009). Effect of poly(ethylene glycol) length on the in vivo behavior of coated quantum dots. Langmuir
  11. (2006). Excitation of nanoscale vapor bubbles at the surface of gold nanoparticles in water.
  12. (2010). Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer. Adv Drug Deliv Rev
  13. (2009). Gastrin releasing protein receptor specific gold nanorods: breast and prostate tumor avid nanovectors for molecular imaging. Nano Lett
  14. (2007). Generating heat with metal nanoparticles. Nano Today
  15. (2010). Generation and detection of plasmonic nanobubbles in zebrafish. Nanotechnology
  16. (2010). Gold nanocages as photothermal transducers for cancer treatment. Small
  17. (2008). Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc Chem Res
  18. (2009). Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects. Photochem Photobiol
  19. (2007). Gold nanorods mediate tumor cell death by compromising membrane integrity. Adv Mater
  20. (2006). Gold nanostructures: engineering their plasmonic properties for biomedical applications. Chem Soc Rev
  21. (2010). Image patterned molecular delivery into live cells using gold particle coated substrates. Opt Express
  22. (2009). In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles. Cancer Lett
  23. (2010). In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. Chem Rev
  24. (2009). Influence of transient environmental photothermal effects on optical scattering by gold nanoparticles. Nano Letters
  25. (2005). Inside-out disruption of silica/gold core-shell nanoparticles by pulsed laser irradiation. Langmuir
  26. (2009). Interaction of nanoparticles with cells. Biomacromolecules
  27. (2009). KTP/LBO laser vaporization of the prostate.
  28. (2008). LANTCET: elimination of solid tumor cells with photothermal bubbles generated around clusters of gold nanoparticles. Nanomedicine
  29. (2009). Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy.
  30. (2006). Metal nanoshells. Ann Biomed Eng
  31. (2008). Metal-based nanorods as molecule-specific contrast agents for reflectance imaging in 3D tissues.
  32. (2010). Multichannel robot for image-guided brachytherapy. BIBE
  33. (2008). Nanoparticle-mediated cellular response is size-dependent.
  34. (2009). Nanoparticles and the brain: cause for concern?
  35. (2010). Nanoshell-mediated photothermal therapy improves survival in a murine glioma model.
  36. (2010). Nonendosomal cellular uptake of ligand-free, positively charged gold nanoparticles. Cytometry A
  37. (2009). Nuclear penetration of surface functionalized gold nanoparticles. Toxicol Appl Pharmacol
  38. (2005). Nucleating cavitation from laser-illuminated nano-particles. Acoust Res Lett Online
  39. (2007). Numerical modeling of short pulse laser interaction with au nanoparticle surrounded by water. Appl Surf Sci
  40. (2000). of America. American national standard for safe use of lasers (ANSI Z136.1–2000). US: Laser Institute of America.
  41. (2006). Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science
  42. (2009). Optical excitation and detection of vapor bubbles around plasmonic nanoparticles. Opt Express
  43. (2010). Optical manipulation of plasmonic nanoparticles, bubble formation and patterning of SERS aggregates. Nanotechnology
  44. (2007). Peptides and metallic nanoparticles for biomedical applications. Nanomedicine
  45. (2004). Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Letters
  46. (2008). Photoacoustic imaging and temperature measurement for photothermal cancer therapy.
  47. (2004). Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain. Nano Letters
  48. (2008). Photothermal bubbles as optical scattering probes for imaging living cells. Nanomedicine
  49. (2010). Photothermal effects of supramolecularly assembled gold nanoparticles for the targeted treatment of cancer cells. Angew Chem Int Ed
  50. (2002). Photothermal monitoring of redox state of respiratory chain in single live cells. Photochem Photobiol
  51. (2005). Photothermal responses of individual cells.
  52. (2010). Plasmonic nanobubbles as transient vapor nanobubbles generated around plasmonic nanoparticles.
  53. (2009). Plasmonic nanoparticle-generated photothermal bubbles and their biomedical applications. Nanomedicine
  54. (2008). Plasmonic photothermal therapy (PPTT) using gold nanoparticles. Lasers Med Sci
  55. (2010). Quantitative evaluation of cellular uptake and trafficking of plain and polyethylene glycol-coated gold nanoparticles. Small
  56. (2002). Rapid molecular theranostics in infectious diseases. Drug Discov Today
  57. (2003). Selective cell targeting with light-absorbing microparticles and nanoparticles.
  58. (2006). Selective laser nano-thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles. Lasers Surg Med
  59. (1983). Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science
  60. (2008). Selective prostate cancer thermal ablation with laser activated gold nanoshells.
  61. (1998). Side firing fiber optic laser probe. Patent number 5772657,
  62. (1995). Side-firing devices for laser prostatectomy.
  63. (2010). Spatiotemporal temperature distribution and cancer cell death in response to extracellular hyperthermia induced by gold nanorods.
  64. (2010). Targeted hyperthermia using metal nanoparticles. Adv Drug Deliv Rev
  65. (2010). Targeted imaging and therapy of brain cancer using theranostic nanoparticles. Mol Pharmaceutics
  66. (2009). The effect of nanoparticle-enhanced photoacoustic stimulation on multipotent marrow stromal cells.
  67. (2008). The evolution of KTP laser vaporization of the prostate.
  68. (2006). The genetic map to theranostics. Med Lab Obs
  69. (2010). The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts. Biomaterials
  70. (2007). The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy. Lasers Surg Med
  71. (2010). Tunable plasmonic nanobubbles for cell theranostics. Nanotechnology
  72. (2010). Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation. Opt Lett