Article thumbnail

Effect of ω-3 Fatty Acid on Gastrointestinal Motility after Abdominal Operation in Rats

By Qun Zhang, Jian-Chun Yu, Wei-Ming Kang and Guang-Jin Zhu


Objective. To investigate whether ω-3 fatty acid could stimulate gastrointestinal motility after abdominal operation. Method. Wistar rats were randomly divided into 3 group (normal saline group, intralipid group, and ω-3 fatty acid group, n = 18/group) after partial caecectomy and gastrostomosis, each group was divided into 3 groups (POD1, POD3, and POD6, n = 6/group). Serum gastrin (GAS), motilin (MTL), interleukin-1 (IL-1), interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), gastric emptying rate, and small bowel propulsion rate were measured. Results. On POD 3, gastric emptying rate and small bowel propulsion rate in ω-3 fatty acid group were higher than those in normal saline group and intralipid group. Serum GAS and MTL levels in ω-3 fatty acid group were higher than those in normal saline group, but serum IL-1, IL-6, TNF-α, and COX-2 levels were lower than those in normal saline group and intralipid group. Conclusion. ω-3 fatty acid could accelerate the recovery of gastrointestinal mobility after abdominal operation in rats, mainly by relieving postoperative inflammation

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2010). B.D.Levy,“Resolvinsandprotectins:naturalpharmacophores for resolution biology,” Prostaglandins Leukotrienes and Essential Fatty Acids,
  2. (1999). Docosahexaenoic acid ingestion inhibits natural killer cell activity and productionofinflammatorymediatorsinyounghealthymen,”Lipids,
  3. (2010). Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions,”
  4. (2010). Fatty acids from fish: the anti-inflammatorypotential of long-chain omega-3fattyacids,”Nutrition Reviews,vol.68,no.5,pp.280– 289,
  5. (2010). Gastrointestinal hormonal dysfunction in gastroparesisandfunctionaldyspepsia,”Neurogastroenterology and Motility,
  6. (2006). h a n g
  7. (2010). M a r t i na n dR .D .S t a p l e t o n ,“ O m e g a - 3f a t t ya c i d si n critical illness,”
  8. (2007). Management of postoperative ileus,”American
  9. (2004). Mechanisms of postoperative ileus,”
  10. (2003). n-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic,”
  11. (2001). S c h w a r z ,J .C .K a l ff,A .T¨ urler et al.,“Prostanoidproduction via COX-2 as a causative mechanism of rodent postoperative ileus,”
  12. (2004). S e r h a n ,M .A r i t a ,S .H o n g ,a n dK .G o t l i n g e r ,“ R e s o l v i n s , docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers,”
  13. (2009). Zdanowicz,“Therapeutic potential of n-3 polyunsaturated fatty acids in disease,”