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Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome

By Stefano Rizza, Ranganath Muniyappa, Micaela Iantorno, Jeong-a Kim, Hui Chen, Philomena Pullikotil, Nicoletta Senese, Manfredi Tesauro, Davide Lauro, Carmine Cardillo and Michael J. Quon

Abstract

Signaling mechanisms were identified by which hesperetin stimulates endothelial nitric oxide production that informed this translational study, demonstrating that oral hesperidin treatment improves endothelial dysfunction

Topics: Hot Topics in Translational Endocrinology
Publisher: Endocrine Society
OAI identifier: oai:pubmedcentral.nih.gov:3085197
Provided by: PubMed Central
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