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The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase

By Kara A. Bernstein, Robert J.D. Reid, Ivana Sunjevaric, Kimberly Demuth, Rebecca C. Burgess and Rodney Rothstein

Abstract

The Shu complex, which contains RAD51 paralogues, is involved in the decision between homologous recombination and error-prone repair. A novel role for the Shu complex in DNA recombination is proposed in which the Shu complex shifts the balance of repair toward Rad51 filament stabilization by inhibiting the disassembly reaction of Srs2

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:3084681
Provided by: PubMed Central
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