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Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure

By Debbie Humphries, Emily Mosites, Joseph Otchere, Welbeck Amoani Twum, Lauren Woo, Hinckley Jones-Sanpei, Lisa M. Harrison, Richard D. Bungiro, Blair Benham-Pyle, Langbong Bimi, Dominic Edoh, Kwabena Bosompem, Michael Wilson and Michael Cappello

Abstract

A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence of hookworm infection was 45%, peaking in those 11–20 years old (58.5%). In children, risk factors for hookworm infection included coinfection with malaria and increased serum immunoglobulin G reactivity to hookworm secretory antigens. Risk factors for infection in adults included poor nutritional status, not using a latrine, not wearing shoes, and occupation (farming). Although albendazole therapy was associated with an overall egg reduction rate of 82%, 37 subjects (39%) remained infected. Among those who failed therapy, treatment was not associated with a significant reduction in egg excretion, and nearly one-third had higher counts on repeat examination. These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance

Topics: Articles
Publisher: The American Society of Tropical Medicine and Hygiene
OAI identifier: oai:pubmedcentral.nih.gov:3083749
Provided by: PubMed Central
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