Article thumbnail

Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

By Hebelin Correa, Fabio Aristizabal, Carmenza Duque and Russell Kerr

Abstract

To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI50 values between 5.8 μM to 12.0 μM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC50 2.9–4.5 μM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC50 3.1–3.8 μM) against E. faecalis, comparable to the reference drug vancomycin (4.2 μM)

Topics: Article
Publisher: Molecular Diversity Preservation International
OAI identifier: oai:pubmedcentral.nih.gov:3083654
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2008). a new pseudopterosin. Tetrahedron Lett.
  2. (2000). A strategy for primary high throughput cytotoxicity screening in pharmaceutical toxicology.
  3. (2009). Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San André s
  4. Bis(nitrobenzoato)copper(II) complexes with nicotinamide, preparation, structure and properties.
  5. (1998). Consideration of some implications of the resistance of biofilms to biocides.
  6. (2003). Drugs from the deep: marine natural products as drug candidates. Drug Discov. Today
  7. (2006). Further studies on the constituents of gorgonian octocoral Pseudopterogorgia elisabethae collected in San André s and Providencia islands, Colombian Caribbean: isolation of a putative biosynthetic intermediate leading to erogorgiane. Tetrahedron
  8. (2005). Identification of amphilectosins as key intermediates in pseudopterosin biosynthesis.
  9. (2003). Identification of anti-inflammatory diterpenes from the marine gorgonian Pseudopterogorgia elisabethae. Tetrahedron
  10. (2005). Marine Natural Products from Pseudopterogorgia elisabethae: structures, biosynthesis, pharmacology, and total synthesis.
  11. (2004). New antibacterial diterpenes from Pseudopterogorgia elisabethae.
  12. (1990). New antiinflammatory pseudopterosins from the marine octocoral Pseudopterogorgia elisabethae.
  13. (2004). New pseudopterosin and seco-pseudopterosin diterpene glycosides from two Colombian isolates of Pseudopterogorgia elisabethae and their diverse biological activities.
  14. (1998). Pharmacological characterization of the pseudopterosins: novel anti-inflammatory natural products isolated from the Caribbean soft coral Pseudopterogorgia elisabethae. Life Sci.
  15. (1992). Phospholipase A2 inhibitors from marine organisms.
  16. Pseudopterogorgia elisabethae de San André s y Providencia, una pluma de mar con excelente potencial como fuente de productos naturales con aplicació n industrial.
  17. (2004). Pseudopterosin content variability of the purple sea whip Pseudopterogorgia elisabethae at the Islands of San André s and Providencia
  18. (2004). Pseudopterosins P-V.New compounds from the gorgonian octocoral Pseudopterogorgia elisabethae from Providencia Island, Colombian Caribbean. Tetrahedron
  19. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
  20. (2006). Terpenoids from marine organisms: unique structures and their pharmacological potential.
  21. (2010). The natural products chemistry of the gorgonian genus Pseudopterogorgia (Octocorallia:Gorgoniidae).
  22. (2010). The odyssey of marine pharmaceuticals: a current pipeline perspective. Trends Pharmacol. Sci.
  23. (1986). The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae.
  24. (1987). The seco-pseudopterosins: new anti-inflammatory diterpene-glycosides from a Caribbean gorgonian octocoral of the genus Pseudopterogorgia. Tetrahedron