Article thumbnail

Adhesion and host cell modulation: critical pathogenicity determinants of Bartonella henselae

By Bettina Franz and Volkhard AJ Kempf

Abstract

Bartonella henselae, the agent of cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis, contains to date two groups of described pathogenicity factors: adhesins and type IV secretion systems. Bartonella adhesin A (BadA), the Trw system and possibly filamentous hemagglutinin act as promiscous or specific adhesins, whereas the virulence locus (Vir)B/VirD4 type IV secretion system modulates a variety of host cell functions. BadA mediates bacterial adherence to endothelial cells and extracellular matrix proteins and triggers the induction of angiogenic gene programming. The VirB/VirD4 type IV secretion system is responsible for, e.g., inhibition of host cell apoptosis, bacterial persistence in erythrocytes, and endothelial sprouting. The Trw-conjugation system of Bartonella spp. mediates host-specific adherence to erythrocytes. Filamentous hemagglutinins represent additional potential pathogenicity factors which are not yet characterized. The exact molecular functions of these pathogenicity factors and their contribution to an orchestral interplay need to be analyzed to understand B. henselae pathogenicity in detail

Topics: Review
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3083372
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2006). A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells.
  2. (2004). a’Aldeen D: Type V protein secretion pathway: the autotransporter story. Microbiol Mol Biol Rev
  3. Adhesins of Bartonella spp.
  4. (2010). al: The BatR/BatS two-component regulatory system controls the adaptive response of Bartonella henselae during human endothelial cell infection.
  5. (2004). al: The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.
  6. (2010). Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease. Parasit Vectors
  7. (2005). Cascales E: Biogenesis, architecture, and function of bacterial type IV secretion systems. Annu Rev Microbiol
  8. (1998). Cat-scratch disease osteomyelitis from a dog scratch.
  9. (2002). Collmer A: HecA, a member of a class of adhesins produced by diverse pathogenic bacteria, contributes to the attachment, aggregation, epidermal cell killing, and virulence phenotypes of Erwinia chrysanthemi EC16 on Nicotiana clevelandii seedlings.
  10. (2003). Dehio C: A bacterial conjugation machinery recruited for pathogenesis. Mol Microbiol
  11. (2009). Dehio C: A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome. Cell Microbiol
  12. (2011). Dehio C: Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells. Cell Microbiol
  13. (2004). Dehio C: The VirB type IV secretion system of Bartonella henselae mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. Mol Microbiol
  14. (2002). Dehio C: The VirB/VirD4 type IV secretion system of Bartonella is essential for establishing intraerythrocytic infection. Mol Microbiol
  15. (2004). et al: Bartonella adhesin A mediates a proangiogenic host cell response.
  16. (2009). et al: Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like sprout formation. Cell Microbiol
  17. (2006). et al: Prevalence of Bartonella species, haemoplasma species, Ehrlichia species, Anaplasma phagocytophilum, and Neorickettsia risticii DNA in the blood of cats and their fleas in the United States. J Feline Med Surg
  18. (2007). et al: Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily. Science
  19. (2008). et al: The head of Bartonella adhesin A is crucial for host cell interaction of Bartonella henselae. Cell Microbiol
  20. (1991). et al: The organism causing bacillary angiomatosis, peliosis hepatis, and fever and bacteremia in immunocompromised patients.
  21. (2006). Kempf VA: Trimeric autotransporter adhesins: variable structure, common function. Trends Microbiol
  22. (2009). Loving CL: Contribution of Bordetella bronchiseptica filamentous hemagglutinin and pertactin to respiratory disease in swine. Infect Immun
  23. (2005). Opinion: Cell entry machines: a common theme in nature? Nat Rev Microbiol
  24. (2001). Raoult D: Immunofluorescent detection of intraerythrocytic Bartonella henselae in naturally infected cats.
  25. (2003). Raoult D: Molecular detection of Bartonella
  26. (2010). Raoult D: Potential for tick-borne bartonelloses. Emerg Infect Dis
  27. (2000). Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins.
  28. (2003). Surface anchoring of bacterial subtilisin important for maturation function. Mol Microbiol
  29. (1990). Tompkins LS: The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens.
  30. (2006). Topology and maturation of filamentous haemagglutinin suggest a new model for two-partner secretion. Mol Microbiol
  31. (2011). VA: Bartonella spp.: throwing light on uncommon human infections.