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The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells

By Aurora Shehu, Constance Albarracin, Y. Sangeeta Devi, Kristin Luther, Julia Halperin, Jamie Le, Jifang Mao, Rachel W. Duan, Jonna Frasor and Geula Gibori

Abstract

Estradiol enhances its own synthesis in breast cancer cells by stimulating transcription of the hsd17b7 gene through ERα activation and NF1 recruitment

Topics: Original Research
Publisher: Endocrine Society
OAI identifier: oai:pubmedcentral.nih.gov:3082328
Provided by: PubMed Central
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