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Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

By Claude M Schofield, Ruby Hsu, Alison J Barker, Caitlyn C Gertz, Robert Blelloch and Erik M Ullian
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3082233
Provided by: PubMed Central

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  1. (2010). DP: Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev
  2. (2001). EA: Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments. Hum Mol Genet
  3. (2009). ER: Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci
  4. (2010). Gogos JA: 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci
  5. (2008). Gogos JA: Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet
  6. (2006). Goldman-Rakic PS: Heterogeneity in the pyramidal network of the medial prefrontal cortex. Nat Neurosci
  7. (2006). Greenberg ME: A brain-specific microRNA regulates dendritic spine development. Nature
  8. (2004). Hannon GJ: MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet
  9. (2008). Huttner WB: miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development
  10. (2005). Impey S: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci USA
  11. (2008). Impey S: An activityregulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci USA
  12. (2009). LaMantia AS: Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci USA
  13. (2006). LaMantia AS: Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Mol Cell Neurosci
  14. (2010). LH: A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature
  15. (2004). Maturation of layer V pyramidal neurons in the rat prefrontal cortex: intrinsic properties and synaptic function.
  16. (2007). R: DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet
  17. (2010). Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron
  18. (2009). Schratt G: Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
  19. (2009). Schratt GM: A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol
  20. (2004). Shiekhattar R: The Microprocessor complex mediates the genesis of microRNAs. Nature
  21. (2007). SM: microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol
  22. (2006). Surani MA: MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res
  23. (2006). The neuronal microRNA system. Nat Rev Neurosci
  24. (2008). Ullian EM: Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.
  25. (2010). Wahlestedt C: MicroRNA dysregulation in psychiatric disease. Brain Res
  26. (2007). Werge T: Brain expressed microRNAs implicated in schizophrenia etiology. PLoS One
  27. (2010). Zakharenko SS: Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.