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Macrophage IL-12p70 Signaling Prevents HSV-1–Induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs

By Kevin R. Mott, David Gate, Mandana Zandian, Sariah J. Allen, Naveen Kumar Rajasagi, Nico van Rooijen, Shuang Chen, Moshe Arditi, Barry T. Rouse, Richard A. Flavell, Terrence Town and Homayon Ghiasi

Abstract

The authors demonstrate that CD4+CD25+FoxP3+ Tregs have an autoaggressive function that is inhibited by macrophage IL-12p70 signaling, resulting in the prevention of HSV-1–induced CNS injury

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3080735
Provided by: PubMed Central
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