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Age-Related Macular Degeneration and the Other Double Helix The Cogan Lecture

By Jayakrishna Ambati


The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD

Topics: Lecture
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3080169
Provided by: PubMed Central
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