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Daily intake of bisphenol A and potential sources of exposure: 2005–2006 National Health and Nutrition Examination Survey

By Judy S LaKind and Daniel Q Naiman


Nationally representative data on urinary levels of bisphenol A (BPA) and its metabolites in the United States from the 2005–2006 National Health and Nutrition Examination Survey (NHANES) were used to estimate daily BPA intakes. In addition, NHANES data on potential sources of BPA exposure and personal characteristics were explored for their association with urinary BPA levels. On the basis of 2005–2006 NHANES urinary BPA data and assumptions described in this paper, median daily intake for the overall population is approximately 34 ng/kg-day. Median daily BPA intakes for men are statistically significantly higher than for women; there is a significant decrease in daily BPA intake with increasing age. Gender- and age-specific median intakes differ from the overall population by less than a factor of 2. Although estimates of daily BPA intake have decreased compared with those from the 2003–2004 NHANES, it is premature to draw conclusions regarding trends at this time, as there is no indication that BPA use declined from 2003 to 2006. On the basis of an assessment of urinary BPA and questionnaire data from the 2005–2006 NHANES, consumption of soda, school lunches, and meals prepared outside the home — but not bottled water or canned tuna — was statistically significantly associated with higher urinary BPA

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  1. (2009). Available at lab_c_generaldoc.pdf,
  2. (2002). Basic anatomical and physiological data for use in radiological protection: reference values:
  3. Bisphenol A (BPA) daily intakes
  4. (2011). Bisphenol A daily intakes in the United States LaKind and Naiman 278
  5. (2009). Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. Eviron Res
  6. (2009). Bisphenol A: where to now? Environ Health Perspect
  7. (2010). Bisphenol-A and disparities in birth outcomes: a review and directions for future research.
  8. (2005). Codebook, and Frequencies. Environmental Phenols and Parabens. Laboratory Survey Years:
  9. (2001). Determination of bisphenol a in effluents of hemodialyzers. Nephron
  10. (2008). Determination of free and total bisphenol A inhuman urine to assess daily uptake as a basis for a valid risk assessment. Toxicol Lett
  11. (2009). Dietary exposure assessment of pregnant women to bisphenol-A from cans and microwave containers in Southern Spain. Food Chem Toxicol
  12. (2008). Environ Health Perspect
  13. (2008). Environmental chemicals in people: challenges in interpreting biomonitoring information. JE n v i r o nH e a l t h
  14. Exposure of the U.S. Population to bisphenol A and 4-tertiary-octylphenol:
  15. (2009). Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect
  16. (2006). Food Safety Authority). Opinion of the Scientific Panel on Food Additives, Flavourings,
  17. for Disease Control and Prevention).
  18. (2009). GerES IV: phthalate metabolites and bisphenol A in urine of German children.
  19. (1996). Graph Stat
  20. (2007). Human exposure to bisphenol A (BPA). Reprod Toxicol
  21. (2008). Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol Appl Pharm
  22. (2009). Levels of bisphenol A in canned soft drink products in Canadian markets. J Agric Food Chem
  23. (2009). Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). Int J Hyg Environ Health
  24. (2008). Long-term study of urinary bisphenol A in elementary school children. Environ Health Prev Med
  25. (2005). Migration of bisphenol A (BPA) from can coatings into a fatty-food stimulant and tuna fish. Food Addit Contam
  26. (2009). Polycarbonate bottle use and urinary bisphenol A concentrations. Environ Health Perspect
  27. (2009). Public health interpretation of trihalomethane blood levels in the United States: NHANES 1999–2004. J Expo Sci Environ Epidemiol 2009; e-pub ahead of print 24
  28. (2003). Publication 89: Basic Anatomical and Physiological Data for Use in Radiological Protection: Reference Values, Elsevier,
  29. (2009). Safety Assessment of BPA
  30. (2008). Sci Environ Epidemiol
  31. (2009). States Environmental Protection Agency). Bisphenol A, Integrated Risk Information System. Available at cfm?fuseactioniris.showQuickView&substance_nmbr0356#reforal, accessed on 13
  32. (2008). Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environ Health Perspect
  33. (2011). This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://