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Discretization Provides a Conceptually Simple Tool to Build Expression Networks

By J. Keith Vass, Desmond J. Higham, Manikhandan A. V. Mudaliar, Xuerong Mao and Daniel J. Crowther


Biomarker identification, using network methods, depends on finding regular co-expression patterns; the overall connectivity is of greater importance than any single relationship. A second requirement is a simple algorithm for ranking patients on how relevant a gene-set is. For both of these requirements discretized data helps to first identify gene cliques, and then to stratify patients

Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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