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Genetic Predisposition for Type 2 Diabetes, but Not for Overweight/Obesity, Is Associated with a Restricted Adipogenesis

By Peter Arner, Erik Arner, Ann Hammarstedt and Ulf Smith
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  15. (2009). Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factoralpha, and inflammation.
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