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Gastric Varices with Remarkable Collateral Veins in Valpronic Acid-Induced Chronic Pancreatitis

By Y. Hattori, T. Higurashi, H. Takahashi, M. Inamori, Y. Abe, Y. Rino and A. Nakajima


Valproic acid (VPA) is a commonly prescribed and approved treatment for epilepsy, including Angelman syndrome, throughout the world. However, the long-term administration of drugs like VPA is associated with the possible development of gastric varices and splenic obstruction as a result of chronic pancreatitis. Such cases can be difficult to treat using endoscopy or interventional radiology because of hemodynamic abnormalities; therefore, surgical treatment is often necessary

Topics: Published: August 2008
Publisher: S. Karger AG
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Provided by: PubMed Central

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