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Irreversible Kidney Damage due to Multicentric Castleman's Disease

By Fredrik Kahn, Anna Fagerström, Mårten Segelmark and Omran Bakoush


Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of the plasma cell variant type with negative Herpes Virus 8. The clinical presentation of this patient was of systemic amyloidosis as a result of both a delayed diagnosis and medical management. Previously described cases of CD with secondary amyloidosis have been of the localized type. Regardless, long-standing clinical remission of CD by cytotoxic drugs and anti-CD20 antibody therapy was achieved, but the nephrotic syndrome remained irreversible

Topics: Case Report
Publisher: CoAction Publishing
OAI identifier: oai:pubmedcentral.nih.gov:3074288
Provided by: PubMed Central
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    1. (2003). A case of multicentric Castleman's disease associated with advanced systemic amyloidosis treated with chemotherapy and anti-CD20 monoclonal antibody. Ann Hematol
    2. (1990). Additive antiproteinuric effect of the NSAID indomethacin and the ACE inhibitor lisinopril.
    3. (2001). Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet
    4. (1995). Castleman disease and renal amyloidosis. Ann Intern Med
    5. (2005). Efficacy of rituximab in an aggressive form of multicentric Castleman disease associated with immune phenomena.
    6. (2004). Fifty years of multicentric Castleman's disease. Acta Oncol
    7. (2005). Gertz MA: Treatment of Castleman's disease.
    8. (2003). Human herpes virus 8 (HHV-8/KSHV) and hematologic malignancies. Rev Clin Exp Hematol
    9. (1972). Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer
    10. (1993). Medical nephrectomy: the last resort for intractable complications of the nephrotic syndrome.
    11. (1995). Secondary amyloidosis associated with Castleman's disease. Intern Med
    12. (2002). Secondary amyloidosis in Castleman's disease: review of the literature and report of a case. Ann Hematol
    13. (1997). Systemic reactive amyloidosis associated with Castleman's disease: serial changes of the concentrations of acute phase serum amyloid A and interleukin 6 in serum.
    14. (2005). The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care.
    15. (1998). The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med
    16. (2002). Unicentric Castleman's disease complicated by systemic AA amyloidosis: a curable disease. Qjm
    17. (1956). VP: Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer

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