Article thumbnail

Acute Regulation of Cardiac Metabolism by the Hexosamine Biosynthesis Pathway and Protein O-GlcNAcylation

By Boglárka Laczy, Norbert Fülöp, Arzu Onay-Besikci, Christine Des Rosiers and John C. Chatham
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3073970
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2008). A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
  2. (2008). A strategy to discover inhibitors of Olinked glycosylation.
  3. (2005). Adenovirusmediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart.
  4. (1999). Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.
  5. (2007). Alpha-lipoic acid increases cardiac glucose oxidation independent of AMPactivated protein kinase in isolated working rat hearts.
  6. (2006). AMPK alterations in cardiac physiology and pathology: enemy or ally?
  7. (2007). Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters.
  8. (2006). Cell signaling, the essential role of O-GlcNAc!
  9. (2001). Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine.
  10. (2007). Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes.
  11. (2008). Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity.
  12. (2007). Cycling of O-linked beta-Nacetylglucosamine on nucleocytoplasmic proteins.
  13. Dell’Italia LJ, Chatham JC (In Press) Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulates hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice. Amino Acids PMID:20676904.
  14. (2003). Diabetes and the accompanying hyperglycemia impairs cardiomyocyte cycling through increased nuclear O-GlcNAcylation.
  15. (2007). Diabetic cardiomyopathy revisited.
  16. (2004). Dynamic actions of glucose and glucosamine on hexosamine biosynthesis in isolated adipocytes: differential effects on glucosamine 6-phosphate, UDP-N-acetylglucosamine, and ATP levels.
  17. (2004). Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia.
  18. (2007). Glucosamine cardioprotection in perfused rat heart associated with increased O-Linked Nacetylglucosamine protein modification and altered p38 activation.
  19. (2009). Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling.
  20. (2008). Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2.
  21. (2004). Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy.
  22. (2006). Hexosamines, insulin resistance, and the complications of diabetes: current status.
  23. (2001). Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
  24. (2006). Identification of the major site of Olinked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1.
  25. (2009). In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation.
  26. (2006). Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia.
  27. (2001). Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats.
  28. (2002). Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36.
  29. (2002). Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.
  30. (2004). Lactate isotopomer analysis by 1H-NMR spectroscopy: consideration of long-range nuclear spin-spin interactions.
  31. (2002). New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36.
  32. (2008). Noncanonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition.
  33. (2010). O-linked beta-N-acetylglucosamine (OGlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress.
  34. (2010). Olinked b-N-acetylglucosamine transferase is indispensable in the failing heart.
  35. (2008). Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells.
  36. (2009). Protein OGlcNAcylation: A new signaling paradigm for the cardiovascular system.
  37. (2005). Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.
  38. (1997). Regulation of energy substrate metabolism in the diabetic heart.
  39. (2008). Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.
  40. (2006). Role of changes in cardiac metabolism in development of diabetic cardiomyopathy.
  41. (2007). Role of protein O-linked N-acetylglucosamine in mediating cell function and survival in the cardiovascular system.
  42. (1967). Studies on L-glutamine D-fructose 6-phosphate amidotransferase. I. Feedback inhibition by uridine diphosphate-N-acetylglucosamine.
  43. (1963). The glucose fattyacid cycle: Its role in insulin sensitivity and metabolic disturbances of diabetes mellitus.
  44. (2004). The hexosamine pathway is responsible for the inhibition by diabetes of phenylephrine-induced inotropy.
  45. (1999). The impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation.
  46. (2005). The impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats.
  47. (2004). The impact of low flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart.
  48. (2007). The impact of Type-2 diabetes and aging on cardiomyocyte function and O-Linked Nacetylglucosamine levels in the heart.
  49. (1984). Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc.
  50. (2003). Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study.
  51. (1997). Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: Involvement of sarcolemmal proteins.