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Genetic Variation in IL28B and Treatment-induced Clearance of Hepatitis C Virus in HIV-Positive Patients With Acute and Chronic Hepatitis C

By Jacob Nattermann, Martin Vogel, Hans Dieter Nischalke, Mark Danta, Stefan Mauss, Hans-Jörg Stellbrink, Axel Baumgarten, Christoph Mayr, Raffaele Bruno, Cristina Tural, Gerd Klausen, Bonaventura Clotet, Uwe Naumann, Thomas Lutz, Michael Rausch, Knud Schewe, Bernhard Bienek, Georg Haerter, Tilman Sauerbruch, Juergen K. Rockstroh and Ulrich Spengler


Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatits C virus–specific treatment in human immunodeficiency virus (HIV)–uninfected and –infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C

Topics: Major Articles and Brief Reports
Publisher: Oxford University Press
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Provided by: PubMed Central
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