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Traveling Bax and Forth from Mitochondria to Control Apoptosis

By Maria Eugenia Soriano and Luca Scorrano

Abstract

Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found primarily in the cytosol. In this issue, Edlich et al., (2011) show that Bax and Bcl-xL interact on the mitochondrial surface and then retrotranslocate to the cytosol, effectively preventing Bax-induced permeabilization of mitochondria

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Publisher: Cell Press
OAI identifier: oai:pubmedcentral.nih.gov:3072571
Provided by: PubMed Central
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