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West Nile Virus RNA Not Detected in Urine of 40 People Tested 6 Years After Acute West Nile Virus Disease

By Katherine B. Gibney, Robert S. Lanciotti, James J. Sejvar, C. Thomas Nugent, Jeffrey M. Linnen, Mark J. Delorey, Jennifer A. Lehman, Erin N. Boswell, J. Erin Staples and Marc Fischer


West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reverse-transcription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease

Topics: Major Articles and Brief Reports
Publisher: Oxford University Press
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Provided by: PubMed Central
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