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Antiviral Activity of Human Immunodeficiency Virus Type 1 Gag-Specific Cytotoxic T Lymphocyte Targeting Is Not Necessarily Intrinsically Superior to Envelope Targeting ▿

By Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng and Otto O. Yang


Across several cohorts, human immunodeficiency virus type 1 (HIV-1) Gag- and Env-specific CD8+ T lymphocyte (CTL) responses have demonstrated inverse and positive correlations, respectively, to viremia. The mechanism has been proposed to be superior antiviral activity of Gag-specific CTLs in general. Addressing this hypothesis, we created two HIV-1 constructs with an epitope translocated from Gag (SLYNTVATL, SL9) to Env, thereby switching the protein source of the epitope. A virus expressing SL9 in Env was similar to the original virus in susceptibility to SL9-specific CTLS. This finding suggests that Env targeting is not intrinsically inferior to Gag targeting for CTL antiviral activity

Topics: Pathogenesis and Immunity
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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