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Posaconazole Serum Concentrations among Cardiothoracic Transplant Recipients: Factors Impacting Trough Levels and Correlation with Clinical Response to Therapy▿

By Ryan K. Shields, Cornelius J. Clancy, Aniket Vadnerkar, Eun J. Kwak, Fernanda P. Silveira, Rima C. Abdel Massih, Joseph M. Pilewski, Maria Crespo, Yoshiya Toyoda, Jay K. Bhama, Christian Bermudez and M. Hong Nguyen


Fifty-six serum posaconazole trough levels were measured in 17 cardiothoracic transplant recipients. Initial levels were ≤0.5, 0.51 to 0.99, and ≥1 μg/ml for 47, 29, and 24% of patients, respectively. Median trough levels associated with therapeutic success were higher than those associated with failure (1.55 versus 0.34 μg/ml; P = 0.006). Patients with levels consistently >0.5 μg/ml were more likely to have successful outcome (P = 0.055). Age ≥65 years, oral administration, and absence of proton pump inhibitors were associated with higher levels of posaconazole (P = 0.006, 0.006, and 0.001, respectively)

Topics: Pharmacology
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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