Timely referral is essential in patients with end-stage renal disease. Time is needed to inform the patient on the options of dialysis or kidney transplantation and for the placement of arteriovenous fistulae if haemodialysis is indicated; early referral is associated with lower morbidity and mortality. A prerequisite for timely referral is that patients with chronic kidney disease are recognised, which involves the following factors: chronic kidney disease should be mentioned in the patient's history; the patient should be informed of the diagnosis; and patients, general practitioners, pharmacists and specialists should have knowledge of the risk factors for acute-on-chronic kidney disease. Timely referral for predialysis requires optimal collaboration between the patient and many health care professionals
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