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The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes

By Hyun Su Ryu, Seung-Yoon Park, Duan Ma, Jin Zhang and Wan Lee
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  7. (2002). Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy.
  8. (2002). Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.
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  10. (2006). Etiology of insulin resistance.
  11. (1989). Fluorescent labeling of mitochondria.
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  14. (2009). Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity.
  15. (1997). Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with noninsulin-dependent diabetes mellitus.
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  19. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes.
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  25. (2008). Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content.
  26. (2004). Mitochondrial diabetes: molecular mechanisms and clinical presentation.
  27. (2005). Mitochondrial dysfunction and type 2 diabetes.
  28. (2006). Mitochondrial dysfunction induces aberrant insulin signalling and glucose utilisation in murine C2C12 myotube cells.
  29. (2004). Mitochondrial signaling: the retrograde response.
  30. (2008). Molecular medicine of microRNAs: structure, function and implications for diabetes.
  31. (2007). Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes.
  32. (1992). Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
  33. (1999). Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk.
  34. (2008). Role of mitochondrial dysfunction in insulin resistance.
  35. (2003). Sequence requirements for micro RNA processing and function in human cells.
  36. (2009). Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance.
  37. (1995). Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
  38. (2008). Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise.
  39. (2001). Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance.
  40. (2008). The cell growth suppressor, mir-126, targets IRS-1.
  41. (2008). The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers.