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HIV Type 1-Mediated Downregulation of HLA-B*57/B*5801 Proteins on Elite Suppressor CD4+ T Cells

By Maame Efua S. Sampah, Christina M. Ceccato and Joel N. Blankson


Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of HLA-B*57 and HLA-B*5801 molecules on primary CD4+ T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of HLA-B*57/B*5801 molecules do not distinguish ES from CP

Topics: Pathogenesis
Publisher: Mary Ann Liebert, Inc.
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Provided by: PubMed Central
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