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Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

By Jun Shirakawa, Hideki Fujii, Kei Ohnuma, Koichiro Sato, Yuzuru Ito, Mitsuyo Kaji, Eri Sakamoto, Megumi Koganei, Hajime Sasaki, Yoji Nagashima, Kikuko Amo, Kazutaka Aoki, Chikao Morimoto, Eiji Takeda and Yasuo Terauchi
Topics: Pathophysiology
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:3064098
Provided by: PubMed Central

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  1. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
  2. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.
  3. (2005). Activity of peroxisomal enzymes, and levels of polyamines in LPA-transgenic mice on two different diets. Lipids Health Dis
  4. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans.
  5. (2010). Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Sci Transl Med
  6. CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1.
  7. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.
  8. (2006). Chronic intake of high-fat and highsucrose diets differentially affects glucose intolerance in mice.
  9. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
  10. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice.
  11. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice.
  12. Diet composition and the metabolic syndrome: what is the optimal fat intake?
  13. Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats.
  14. Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice.
  15. (2007). Dipeptidyl peptidase-4 inhibitors: clinical data and clinical implications. Diabetes Care
  16. (1999). Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
  17. Exendin-4, a glucagonlike protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice.
  18. (2008). Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res
  19. GLP-1 and extra-islet effects.
  20. Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.
  21. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.
  22. Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells.
  23. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat dietinduced insulin resistance.
  24. (2008). Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev
  25. Hepatic adaptations to sucrose and fructose.
  26. Impact of GLP-1 and GLP-1 receptor agonists on cardiovascular risk factors in type 2 diabetes. Curr Diabetes Rev 2010;6:191–
  27. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.
  28. Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/ endothelial interactions in diabetic db/db mice.
  29. (2007). Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol
  30. (2006). Inflamed fat: what starts the fire?
  31. Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
  32. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagonlike peptide-1 receptor agonist,
  33. (2006). LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226)
  34. Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling.
  35. Metabolic effects of fructose.
  36. Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease.
  37. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.
  38. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research.
  39. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration.
  40. Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
  41. (1995). Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
  42. Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.
  43. Soluble CD26/dipeptidyl peptidase IV induces T cell proliferation through CD86 up-regulation on APCs.
  44. (2008). T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol
  45. (2011). The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice.
  46. (2008). The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res
  47. The role of fat topology in the risk of disease.