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Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue

By Hayley T. Nicholls, Greg Kowalski, David J. Kennedy, Steve Risis, Lee A. Zaffino, Nadine Watson, Peter Kanellakis, Matthew J. Watt, Alex Bobik, Arend Bonen, Maria Febbraio, Graeme I. Lancaster and Mark A. Febbraio
Topics: Metabolism
Publisher: American Diabetes Association
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Provided by: PubMed Central

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  22. Ceramides in insulin resistance and lipotoxicity.
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  27. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.
  28. IKK-beta links inflammation to obesity-induced insulin resistance.
  29. Inflammation and metabolic disorders.
  30. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.
  31. (2010). Interleukin-6 deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia
  32. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction.
  33. (2007). JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab
  34. (2002). Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes
  35. Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle.
  36. Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance.
  37. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
  38. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.
  39. (2006). Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells.
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  41. Response to staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.
  42. (2011). Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain.
  43. Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/ CD36)-mediated cellular fatty acid uptake.
  44. (2009). The role of the scavenger receptor CD36 in regulating mononuclear phagocyte trafficking to atherosclerotic lesions and vascular inflammation. Cardiovasc Res
  45. TLR4 links innate immunity and fatty acid-induced insulin resistance.