Article thumbnail

Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications

By Mohd Wajid Ali Khan, Kamalpreet Banga, Subhash N Mashal and Wahid Ali Khan
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1976). A rapid and sensitive method for quantitation of micrograms quantity of protein utilizing the principle of protein dye binding. Anal Biochem
  2. (1998). Calcinaro F: Controversies on humoral immune markers of insulin-dependent diabetes mellitus.
  3. (2009). Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes. Autoimmunity
  4. (2000). Epitope spreading and a varying but not disease-specific GAD65 antibody response in type I diabetes: the Childhood Diabetes in Finland Study Group. Diabetologia
  5. (1994). FA: GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes
  6. (2001). Fuller JH: Microalbuminuria in type 1 diabetes: rate, risk factors and glycemic threshold. Kidney Int
  7. (2004). Hampe CS: Multiplicity of the antibody response to GAD65 in type I diabetes. Clin Exp Immunol
  8. (2003). Hampe CS: Recombinant Fab of human mAbs specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Ab. Diabetes
  9. (1995). Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetol
  10. (2009). JM: RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.
  11. (1999). Kurien BT: Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse. Arthritis Rheum
  12. (1999). Lernmark A: Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes. Horm Metab Res
  13. (2000). Lernmark A: Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes.
  14. (2008). MJ: COOH-Terminal Clustering of autoantibody and Tcell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes
  15. (2004). Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient. Clin Exp Immunol
  16. (2008). Moinuddin : Enhanced binding of circulating SLE autoantibodies to catecholestrogen-copper-modifed DNA. Mol Cell Biochem
  17. (1994). Nagataki S: Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes
  18. (1998). Protein sulfhydryl oxidation in short-term diabetic rabbit liver and kidney tissues.
  19. (2000). Quantification and significance of protein oxidation in biological samples. Drug Met Rev
  20. (2004). Rietbrock N: Advance glycation end-products and the progress of diabetic vascular complications. Physiol Res
  21. (1994). Shacter E: Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol
  22. (1918). The adsorption of gases on plane surface glass, mica and platinum. J Am Chem Soc
  23. (1999). Thorpe SR: Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes
  24. (1978). Use of staphylococcal protein A as immunological reagent.
  25. (2002). Xanthine oxidase is involved in free radical production in type 1 diabetes. Diabetes