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A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics

By Marla M Spain and Chhabi K Govind

Abstract

Histone acetylation modulates histone occupancy both at promoters and in coding sequences. Based on our recent observation that HDACs in the budding yeast, Saccharomyces cerevisiae, are co-transcriptionally recruited to coding regions by elongating polymerases, we propose a model in which Pol II facilitates recruitment of chromatin remodeling complexes as well as other factors required for productive elongation

Topics: Point-of-View
Publisher: Landes Bioscience
OAI identifier: oai:pubmedcentral.nih.gov:3062398
Provided by: PubMed Central
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