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Genetic Requirement for Mutagenesis of the G[8,5-Me]T Cross-Link in Escherichia coli: DNA Polymerases IV and V Compete for Error-Prone Bypass

By Paromita Raychaudhury and Ashis K. Basu
Publisher: American Chemical Society
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Provided by: PubMed Central

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  5. Box,H.C.,Dawidzik,J.B.,andBudzinski,E.E.(2001)Freeradicalinduced double lesions in DNA.
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  11. (2002). DNA polymerase V-dependent mutator activity in an SOS-induced Escherichia coli strain with a temperature-sensitive DNA polymerase III.
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  13. (2002). Error-prone repair DNA polymerases in prokaryotes and eukaryotes.
  14. Evans,M.D.,Dizdaroglu,M.,andCooke,M.S.(2004)Oxidative DNAdamageanddisease:Induction,repairandsignificance.Mutat.Res.
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  17. (2011). Highly mutagenic replication by DNA polymerase V (UmuC)2338 |Biochemistry
  18. (2007). In vivo formation and in vitro replication of a guanine-thymine intrastrand cross-link lesion.
  19. (1991). Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage.
  20. (1992). Measurement of radiation-induced damage to DNA at the molecular level.
  21. (2010). Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.
  22. (2010). Multiple twopolymerase mechanisms in mammalian translesion DNA synthesis.
  23. (2007). Mutagenicity of the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in mammalian cells.
  24. (2008). Mutational specificity of γ-radiation-induced guanine-thymine and thymineguanine intrastrand cross-links in mammalian cells and translesion synthesis past the guanine-thymine lesion by human DNA polymerase η.
  25. (1996). or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells.
  26. (2000). Oxidants, oxidative stress and the biology of ageing.
  27. (1997). Oxidative damage to DNA: Formation, measurement, and biological significance.
  28. (2001). P r a k a s h ,L . ,P r a k a s h ,S . ,T o d o ,T . ,W a l k e r ,G .C . ,W a n g ,Z . ,a n d
  29. (1996). Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA).
  30. (2006). Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nuclease.
  31. (2005). Recognition and incision of γ-radiation-induced cross-linked guaninethymine tandem lesion G[8,5-Me]T by UvrABC nuclease.
  32. (2010). Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by HumanandYeastDNAPolymeraseη.J.NucleicAcids2010,No.101495.
  33. Roles of chromosomal and episomal dinB genes encoding DNA pol IV in targeted and untargeted mutagenesis in Escherichia coli.
  34. (1993). Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-Oxoguanine in DNA induces targeted G.C f T.A transversions in simian kidney cells.
  35. (2009). Structural insight into translesion synthesis by DNA Pol II.
  36. (2001). Structure of the replicating complex of a pol R family DNA polymerase.
  37. (2009). The active form of DNA polymerase V is UmuD0(2)CRecA-ATP.
  38. (1997). The Escherichia coli polB locus is identical to dinA, the structural gene for DNA polymerase II. Characterization of Pol II purified from a polB mutant.
  39. (1991). The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 30 thymine-tocytosine transitions in Escherichia coli.
  40. (2005). Thermodynamic and in vitro replication studies of an intrastrand G[8-5]C cross-link lesion.
  41. (2007). Translesion synthesis in Escherichia coli: Lessons from the NarI mutation hot spot.
  42. (2009). Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals.
  43. (2007). UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB.