Article thumbnail

A TRP channel contributes to insulin secretion by pancreatic β-cells

By Emily R Liman


The release of insulin by pancreatic β-cells involves a complex interplay of conductances that generate oscillations and drive secretion. A recent report identifies a new player in this process, the ion channel TRPM 5. TRPM 5 was originally identified in taste cells, where it forms a Ca2+-activated cation channel that is required for sensory responses to bitter and sweet tastes. New research now shows that TRPM 5 is expressed within the pancreatic islets of Langerhans, where it regulates the frequency of Ca2+ oscillations and contributes to insulin release by β-cell

Topics: Commentary
Publisher: Landes Bioscience
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles