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Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD

By Carla Winkler, Elena N Atochina-Vasserman, Olaf Holz, Michael F Beers, Veit J Erpenbeck, Norbert Krug, Stefan Roepcke, Gereon Lauer, Martin Elmlinger and Jens M Hohlfeld
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2005). A: Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease. Arch Intern Med
  2. (2009). Agusti A: Immunologic aspects of chronic obstructive pulmonary disease.
  3. (2010). AJ: Review: Chemical and structural modifications of pulmonary collectins and their functional consequences. Innate Immun
  4. (2004). Batenburg JJ: Serum surfactant protein D is elevated in allergic patients. Clin Exp Allergy
  5. (1991). Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal Biochem
  6. (2006). Chakraborty T: Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol
  7. (1996). Crouch EC: Biosynthesis of surfactant protein D. Contributions of conserved NH2-terminal cysteine residues and collagen helix formation to assembly and secretion.
  8. (2009). Crouch EC: Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
  9. (2010). DD: Integrating lung and plasma expression of pneumo-proteins in developing biomarkers in COPD: a case study of surfactant protein D. Med Sci Monit
  10. (2008). Dubinett SM: Smoking and lung cancer: the role of inflammation. Proc Am Thorac Soc
  11. (2006). Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers. Environ Health Perspect
  12. (2007). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med
  13. (2008). Gow AJ: S-nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biol
  14. (2008). Haczku A: Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir Res
  15. (2003). Henson PM: By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell
  16. (2006). Hohlfeld JM: Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Allergy
  17. (2005). Holmskov U: A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.
  18. (2000). Holmskov U: Localization of lung surfactant protein D on mucosal surfaces in human tissues.
  19. (2010). Holmskov U: Long-term stability and circadian variation in circulating levels of surfactant protein D. Immunobiology
  20. (2000). Ikegami M: Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol
  21. (2005). Immunoregulatory functions of surfactant proteins. Nat Rev Immunol
  22. (2002). Kohno N: Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases. Am J Respir Crit Care Med
  23. (1999). Lung epithelium-specific proteins: characteristics and potential applications as markers.
  24. (2004). MF: Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein Adeficient mice: attenuation of cytokine responses and reactive oxygennitrogen species. Infect Immun
  25. (1994). Molecular structure of pulmonary surfactant protein D (SP-D).
  26. Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis.
  27. (2006). Oxidative damage to surfactant protein D in pulmonary diseases. Free Radic Res
  28. (1995). Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids. Am J Respir Crit Care Med
  29. (2004). Remold-O’Donnell E, Belaaouaj A: Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
  30. (2007). SP: Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm Med
  31. (2009). Tal-Singer R: Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J
  32. (2002). The intrauterine expression of surfactant protein D in the terminal airways of human fetuses compared with surfactant protein A. Eur J Pediatr