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The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

By Peter Connick, Madhan Kolappan, Rickie Patani, Michael A Scott, Charles Crawley, Xiao-Ling He, Karen Richardson, Kelly Barber, Daniel J Webber, Claudia AM Wheeler-Kingshott, Daniel J Tozer, Rebecca S Samson, David L Thomas, Ming-Qing Du, Shi L Luan, Andrew W Michell, Daniel R Altmann, Alan J Thompson, David H Miller, Alastair Compston and Siddharthan Chandran
Topics: Methodology
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2006). Aigner L: Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem Cells
  2. (2005). AJ: Adaptive cortical plasticity in higher visual areas after acute optic neuritis. Ann Neurol
  3. (2007). AJ: Rating scales as outcome measures for clinical trials in neurology: problems, solutions, and recommendations. Lancet Neurol
  4. (2006). Alexander DC: Camino: Open-Source Diffusion-MRI Reconstruction and
  5. (2000). Analysis of pretest-posttest designs.
  6. (2007). BENEFIT Study Group: Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study. Lancet
  7. (2008). Coles AJ: Multiple Sclerosis. Lancet
  8. (2002). De Stefano N: Accurate, robust, and automated longitudinal and crosssectional brain change analysis. Neuroimage
  9. (2008). Developmental Committee of the European Group for Blood and Marrow Transplantation: Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet
  10. (2009). DH: Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis.
  11. (2001). DH: Detection of optic nerve atrophy following a single episode of unilateral optic neuritis by MRI using a fat-saturated short-echo fast FLAIR sequence. Neuroradiology
  12. (2006). DH: In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls.
  13. (2007). Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study. Iran J Immunol
  14. (1999). DR: Multilineage potential of adult human mesenchymal stem cells. Science
  15. (2006). Du MQ: Application of array CGH on archival formalin-fixed paraffinembedded tissues including small numbers of microdissected cells. Lab Invest
  16. (1995). Frackowiak RSJ: Statistical parametric maps in functional imaging: A general linear approach. Human Brain Mapping
  17. (2006). Horwitz E: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy
  18. (2005). Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp Neurol
  19. (1970). Linnemann F: The course of multiple sclerosis in 73 cases with computer-designed curves. Acta Neurol Scand
  20. (2006). Neuroprotection in multiple sclerosis: therapeutic strategies and clinical trial design. Curr Opin Neurol
  21. (2004). Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T. Neuroimage
  22. (2005). Ordidge RJ: 3D MDEFT imaging of the human brain at 4.7T with reduced sensitivity to RF inhomogeneity.
  23. (1976). PR: Course of multiple sclerosis: first results of a prospective study carried out of 102 MS patients from
  24. (2009). RH: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia
  25. (2010). Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol
  26. (2008). Tandon PK: Alemtuzumab vs. interferon beta-1a in early multiple sclerosis.
  27. (2005). Uccelli A: Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood
  28. (1995). U─čurbil K: High contrast and fast three-dimensional magnetic resonance imaging at high fields. Magn Reson Med