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Malignant transformation of intrathoracic ancient neurilemmoma in a patient without Von Recklinghausen's disease.

By Young Chae Chu, Yong Han Yoon, Hye Seung Han, Jee Young Han, Joon Mee Kim and In Suh Park


Malignant transformation of a neurilemmoma is an exceedingly rare event. We describe a case of intrathoracic ancient neurilemmoma undergoing a malignant change in a 39-yr-old man. The patient presented with right flank and chest pain for several months. Plain radiography and CT scan of the chest showed a soft tissue mass lesion at the extrapleural space with erosion of surrounding ribs at the right basal lung area. The excised mass was encapsulated and measured 4.5 x 3.5 x 2.3 cm. The cut surface showed grayish-white and glistening with a focal cystic change and hemorrhage. Necrosis was not seen. Histologically, the tumor showed the features of classic neurilemmoma composed of the Antoni type A and B areas with perivascular hyalinization. In addition, obviously histo-logically malignant foci manifested by presence of markedly increased cellularity with fascicular arrangement, active mitotic activity, hyperchromasia, and gradual loss of original neurilemmomatous feature were noted

Topics: Research Article
Publisher: Korean Academy of Medical Sciences
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Provided by: PubMed Central

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  4. (1985). Epithelioid neurilemoma of the trigeminal nerve: an immunohistochemical and ultrastructural study. Histopathology
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  7. (1993). Glandular peripheral nerve sheath tumors. A study of eleven cases and review of the literature. Cancer
  8. (1999). Intraneural angiosarcoma and angiosarcoma arising in benign and malignant peripheral nerve sheath tumors: clinicopathological and immunohistochemical analysis of four cases. Histopathology
  9. (1985). Malignant epithelioid schwannoma arising in a benign schwannoma. Cancer
  10. (1989). Malignant nerve sheath tumor arising in a benign ancient schwannoma. Histopathology
  11. (1986). Malignant peripheral nerve sheath tumor. A clinicopathologic study of 120 cases. Cancer
  12. (1984). Malignant peripheral nerve sheath tumors arising from ganglioneuromas.
  13. (1990). Malignant peripheral nerve sheath tumors of the buttock and lower extremity. A study of 43 cases. Cancer
  14. (1984). Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer
  15. (1982). Malignant transformation of intrathoracic ancient neurilemoma in a patient without von Recklinghausen’s disease. Acta Pathol Jpn
  16. (1969). Malignant trasformation of a benign encapsulated neurilemoma.
  17. (1960). Neurogenous neoplasms of the mediastinum. Cancer
  18. (1973). Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant “Triton” tumors). Cancer
  19. (1983). Postirradiation neurofibrosarcoma. Cancer
  20. (1980). Radiation induced malignant and atypical peripheral nerve sheath tumors. Ann Neurol
  21. (1990). Recurrence of acoustic neurilemmoma as a malignant spindle cell neoplasm.
  22. (1994). Schwannoma (Neurilemoma) with malignant transformation: a rare, distinctive peripheral nerve tumor.
  23. (1986). The purely epithelioid malignant nerve sheath tumor.
  24. (2001). Vestibular Schwannoma with malignant transformation: a case report.