Article thumbnail

The effect of dietary intervention through the modification of fatty acids composition and antioxidant vitamin intake on plasma TXB(2) level in Korean postmenopausal women with hypercholesterolemia.

By Kyungah Jung, Sangyeon Kim, Jeongik Woo and Yookyung Chang


The purpose of this study was to observe the effects of dietary intervention, through the modification of dietary fatty acids composition and antioxidant vitamins, on plasma thromboxane B(2) (TXB(2)) levels in postmenopausal women with hypercholesterolemia. The subjects were treated for 12 weeks with one of three methods: hormone replacement therapy (HRT group, n=8), dietary intervention (DIET group, n=8), or HRT combined with dietary intervention (HRT +DIET group, n=8). Changes in serum phospholipid fatty acids composition, serum peroxides, and plasma TXB(2) levels were measured at weeks 0, 4 and 12. The P/S ratio increased and the n-6/ n-3 ratio decreased in the DIET and the HRT +DIET group at week 4 (p<0.05). The ratio of C20:5/C20:4 in serum phospholipid increased in the DIET (p<0.05) and the HRT +DIET groups (NS) at week 4. Plasma TXB(2) levels decreased in the DIET (-35%, p<0.05) and the HRT +DIET groups (-18.8%, NS) at week 4. Serum lipid peroxides levels significantly decreased by 10.5% and 15.2% in the DIET group at weeks 4 and 12, and by 10.8% in the HRT +DIET group only at week 12 (p<0.05). Dietary intervention may lower thrombotic risks in Korean postmenopausal women by changing the serum fatty acid composition, serum lipid peroxides levels and plasma thromboxane B(2) levels

Topics: Research Article
Publisher: Korean Academy of Medical Sciences
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1976). A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med
  2. (1957). A simple method for the isolation and purification of total lipids from animal tissue.
  3. (1997). A study of the dietary intake status and one portion size of commonly consumed food and dishes in Korean elderly women.
  4. (2001). Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids
  5. (1993). Antioxidants and cardiovascular disease: A review.
  6. (2000). Biochemical effects of a diet containing foods enriched with n-3 fatty acids.
  7. (1992). Can changes in dietary fatty acid intake lead to changes in physiologic responses related to thrombosis?
  8. (2000). Comparisons of nutrients intake of normocholesterolemia and hypercholesterolemia in the postmenopausal women.
  9. (1999). Contribution of trends in survival and coronaryevent rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA Project population. Lancet
  10. (1991). Coronary heart disease: seven dietary factors. Lancet
  11. (2000). Development of a semi-quantitative food frequency questionnaire to assess dietary intake of the elderly women in Korea.
  12. (1994). Diet and lifestyle modification and its relationship to atherosclerosis. Med Clin North Am
  13. (1996). Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women.
  14. (1997). Dietary fatty acids in human thrombosis and haemostasis.
  15. (1990). Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms.
  16. (1983). Effect of eicosapentaenoic acid on the platelet aggregation and composition of fatty acid in man. Atherosclerosis
  17. (1991). Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status.
  18. (1997). Effects of estradiol and medroxyprogesterone-acetate treatment on erythrocyte antioxidant enzyme activities and malondialdehyde plasma levels in amenorrhoic women.
  19. (1987). Eicosanoid biosynthesis in human cardiovascular disease. Hum Pathol
  20. (2001). Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components.
  21. (1989). Epidemiology and risk factors for coronary heart disease in women. Cardiovasc Clin
  22. (1989). Evidence for the presence of oxidatively modified low-density lipoprotein in atherosclerotic lesions of rabbits and man.
  23. (1992). Factors related to the plasma fatty acid profile in healthy subjects, with special reference to antioxidant micronutrient status: a multi314
  24. (1992). Factors related to the plasma fatty acid profile in healthy subjects, with special reference to antioxidant micronutrient status: a multivariate analysis.
  25. (1979). Hemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet
  26. (1995). Hennekens CH. A secondary prevention trial of antioxidant vitamins and cardiovascular disease in women. Ann Epidemiol
  27. (1995). How do we explain the clinical benefits of estrogen? From bedside to bench. Circulation
  28. (1993). Hyperlipidaemia and hypercoagulability. Prog Lipid Res
  29. (1992). Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.
  30. (1993). Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C.
  31. (1984). Increased serum lipid peroxides initiate atherogenesis. Bioassays
  32. (1989). Influence of carotene supplementation on serum carotene and retinal levels in lactoovovegetarian and nonvegetarian women.
  33. (1989). Lipid peroxides and atherosclerosis. BMJ
  34. (1999). Office Republic of Korea. Annual report on the cause of death statistics,
  35. (1992). Olive oil, corn oil, and n-3 fatty acids differently affect lipids, lipoproteins, platelets and superoxide formation in type II hypercholesterolemia.
  36. (1994). Oxidized lipoproteins in atherosclerosis and thrombosis.
  37. (1982). Plasma and erythrocyte membrane fatty acids in oral contraceptive users. Clin Chim Acta
  38. (1986). platelet function and composition in nine groups of French and British farmers. Atherosclerosis
  39. (1980). Platelet-membrane fatty acids, platelet aggregation, and thromboxane formation during a mackerel diet. Lancet
  40. (1998). Preliminary study on platelet aggregation in postmenopausal women consuming extra virgin olive oil and high oleic acid sunflower oil.
  41. (1964). Preparation of fatty acid methylesters and dimethyl acetals from lipids with boron fluoride methanol.
  42. (1984). Relative fatty acid composition of lecithin during postmenopausal replacement therapy: a comparison between ethinyl estradiol and estradiol valerate. Gynecol Obstet Invest
  43. (1981). Separative determination of ascorbic acid and erythrobic acid in animal tissues by high performance liquid chromatography.
  44. (1979). Simultaneous determination of alpha-tocopherol and retinal in plasma or red blood cell by high performance liquid chromatography.
  45. (1980). The composition of the Eskimo food in northwestern Greenland.
  46. (1993). The effect of estrogen replacement therapy on platelet aggregation and adenosine triphosphate release in postmenopausal women. Obstet Gynecol
  47. (1999). Validation study of a self-administered semi-quantitative food frequency questionnaire among postmenopausal women in Seoul. Master thesis.
  48. (1977). Vitamin E deficiency and enhanced platelet function: reversal following E supplementation.
  49. (1992). Workshop on dietary fatty acids and thrombosis.