Article thumbnail

Vestibular schwannoma with malignant transformation: a case report.

By E. I. Son, I. M. Kim and S. P. Kim

Abstract

We describe a rare case of malignant transformation in a vestibular schwannoma in a 33-yr-old woman. She presented herself with headache, tinnitus, and hearing loss and underwent posterior fossa explorations three times during the short period of 3 months. The clinicopathological features of the original tumor were typical of benign vestibular schwannoma. Despite a complete microsurgical excision, two months later, the tumor recurred locally with a rapid increase in size causing a progressive worsening of neurological symptoms. A diagnosis of malignant schwannoma was made for the recurrent tumor on the basis of the microscopic findings of high cellularity, moderate pleomorphism, and the presence of mitotic cells. Repeat magnetic resonance imaging performed a month after the second surgery unexpectedly showed definite tumor enlargement. She remained clinically stable following the third debulking of the tumor and adjuvant radiotherapy. We propose that this recurrent tumor represent malignant transformation from a benign vestibular schwannoma which was an unusual occurrence in a patient without neurofibromatosis

Topics: Research Article
Publisher: Korean Academy of Medical Sciences
OAI identifier: oai:pubmedcentral.nih.gov:3054799
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1996). Clinical significance of Ki-67 staining index in acoustic neurinoma. Neurol Med Chir
  2. (1998). Death from a malignant cerebellopontine angle triton tumor despite stereotactic radiosurgery: case report.
  3. (1983). Malignant nerve sheath tumor of acoustic nerve. Arch Pathol Lab Med
  4. (1987). Malignant triton tumor in the cerebellopontine angle: report of a case. Acta Neuropathol (Berl)
  5. (1992). Malignant triton tumor of the acoustic nerve: case report.
  6. (1999). MIB-1 and schwannoma.
  7. (1995). Mod Pathol
  8. (2000). Primary intracranial malignant schwannoma of trigeminal nerve. A case report with review of the literature. Acta Neurochir (Wien)
  9. (1983). Primary malignant nerve sheath tumor of the gasserian ganglion. A report of two cases. Neurosurgery
  10. (1990). Recurrence of acoustic neurilemoma as a malignant spindle-cell neoplasm.
  11. (1994). Schwannoma (Neurilemoma) with malignant transformation: a rare, distinctive peripheral nerve tumor.
  12. (1998). Tumors of the cranial, spinal, and peripheral nerve sheaths.