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PI 3-Kinase/Rac1 and ERK1/2 Regulate FGF-2–Mediated Cell Proliferation through Phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2

By Jeong Goo Lee and EunDuck P. Kay


FGF-2 required both PI 3-kinase/Rac1 and ERK activation for cell proliferation, after which the two signals used the common pathways for phosphorylating p27 but used differential kinetics and pathways: Ser-10 by KIS and Thr-187 by Cdc25A/Cdk2

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Publisher: Association for Research in Vision and Ophthalmology, Inc.
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