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Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice

By Majda Hadziahmetovic, Ying Song, Padmavathi Ponnuru, Jared Iacovelli, Allan Hunter, Nadine Haddad, John Beard, James R. Connor, Sophie Vaulont and Joshua L. Dunaief

Abstract

Hepcidin is an iron regulatory hormone expressed in the retina. In the present study, evidence from mice and tissue culture suggest that hepcidin is upregulated in response to increased retinal iron levels and normally serves to prevent retinal iron excess

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3053271
Provided by: PubMed Central
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