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Adipose inflammation: cause or consequence of obesity-related insulin resistance

By Ping Jiao and Haiyan Xu

Abstract

Obesity constitutes a critical risk factor for the development of many life threatening diseases, particularly insulin resistance and type 2 diabetes. Adipose tissue plays an important role in regulating whole body energy homeostatsis and obesity-related insulin resistance. Inflammation has been commonly linked to insulin resistance. Recent studies demonstrated that adipose tissue is an important source for producing inflammatory molecules in the obese state, primarily due to accumulation of macrophages. Animal models deficient in key inflammatory molecules or with reduced adipose macrophage infiltration are protected from development of obesity-related insulin resistance. Repression of adipose inflammation may be a useful approach to ameliorate obesity-associated metabolic disorders

Topics: Review
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:3052712
Provided by: PubMed Central

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Citations

  1. (2002). A central role for JNK in obesity and insulin resistance.
  2. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
  3. (1999). A role for preadipocytes as macrophage-like cells.
  4. (2007). Absence of CC chemokine ligand 2 does not limit obesity-associated infi ltration of macrophages into adipose tissue.
  5. (2005). Adipocyte death defi nes macrophage localization and function in adipose tissue of obese mice and humans.
  6. (2007). Adipocyte death, adipose tissue remodeling, and obesity complications.
  7. (1993). Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
  8. (2002). Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell,
  9. (2002). Altered tumor necrosis factoralpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.
  10. (1957). Aspirin and diabetes mellitus.
  11. (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.
  12. (2006). CCR2 modulates infl ammatory and metabolic effects of high-fat feeding.
  13. (2001). Chemokines control fat accumulation and leptin secretion by cultured human adipocytes.
  14. (2003). Chronic infl ammation in fat plays a crucial role in the development of obesity-related insulin resistance.
  15. (2002). Elevated levels of acutephase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.
  16. et al.1993. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.
  17. (2004). Evidence for a potent antiinfl ammatory effect of rosiglitazone.
  18. (2002). Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.
  19. (2005). Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes,
  20. (1998). Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.
  21. (2002). High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes.
  22. (2005). IKK-beta links infl ammation to obesity-induced insulin resistance.
  23. (1995). Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
  24. (2006). Increased infi ltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity.
  25. (2003). Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects.
  26. (1997). KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-alpha production. Life Sci,
  27. (2005). Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.
  28. (2007). Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.
  29. (2006). Low-dose rosiglitazone exerts an antiinfl ammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics.
  30. (2007). Macrophage infi ltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity.
  31. (2007). Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
  32. (2007). Macrophagespecifi c PPARgamma controls alternative activation and improves insulin resistance.
  33. (2006). MCP-1 contributes to macrophage infi ltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.
  34. (2003). Monocyte chemoattractant protein 1 in obesity and insulin resistance.
  35. (2008). Neutrophils transiently infi ltrate intra-abdominal fat early in the course of high fat feeding.
  36. (1997). NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome
  37. (1998). Obesity and diabetes in TNF-alpha receptor- defi cient mice.
  38. (2003). Obesity and the environment: where do we go from here?
  39. (2000). Obesity as a medical problem.
  40. (2007). Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
  41. (2003). Obesity is associated with macrophage accumulation in adipose tissue.
  42. (1901). On the treatment of glycosuria and diabetes mellitus with sodium salicylate.
  43. (2006). Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.
  44. (2000). Peroxisome proliferatoractivated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-defi cient mice.
  45. (2007). PPARgamma activation primes human monocytes into alternative M2 macrophages with antiinfl ammatory properties. Cell Metab,
  46. (2003). Preadipocyte conversion to macrophage. Evidence of plasticity.
  47. (1997). Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.
  48. (1959). Reappraisal of the hypoglycemic action of acetylsalicylate.
  49. (1994). Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
  50. (1959). Reduction of blood fi brinolytic activity in diabetes mellitus by insulin.
  51. (2005). Reduction of macrophage infi ltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss.
  52. (2001). Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
  53. (2001). Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.
  54. (1967). Serum concentration of alpha-2-macroglobulin, haptoglobin and alpha-1-antitrypsin in diabetes mellitus.
  55. (1993). Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus. Clin Chim Acta,
  56. (2001). Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation.
  57. (2001). Suppression of nuclear factorkappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-infl ammatory effect and a potential antiatherosclerotic effect in the obese.
  58. (1997). Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.
  59. (2007). The anti-atherogenic effects of thiazolidinediones. Curr Diabetes Rev,
  60. (2006). TLR4 links innate immunity and fatty acid-induced insulin resistance.
  61. (1999). Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1.
  62. (1994). Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase.
  63. (2008). Visceral adipose tissue infl ammation accelerates atherosclerosis in apolipoprotein E-defi cient mice.
  64. (2004). Weight loss regulates infl ammation-related genes in white adipose tissue of obese subjects.