The title compound, C28H24N4O4·H2O, crystallizes with two organic molecules and two solvent water molecules in the asymmetric unit. The most obvious difference between the molecules is the torsion angles between the isoxazole ring and the benzene and phenyl rings [47.0 (2)/56.4 (2) and 33.3 (2)/11.0 (2)°, respectively]. Another important difference is observed in the rotation of the nitro group with respect to the phenyl groups [3.5 (6) and 31.1 (6)°]. The pyrrolidinone fragment is cis oriented with respect to the 4-nitrophenyl fragment. In the crystal, molecules are linked into centrosymmetric R 4 2(8) and R 4 4(20) motifs by O—H⋯O and N—H⋯O interactions
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