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Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat

By Francesco Napoletano, Simona Occhi, Piera Calamita, Vera Volpi, Eric Blanc, Bernard Charroux, Julien Royet and Manolis Fanto

Abstract

Dentatorubral-pallidoluysian Atrophy is a neurodegenerative disease caused by the expansion of a CAG stretch in the atrophin-1 gene. The findings of this study report that Atrophin promotes neurodegeneration in Drosophila by repressing the expression of the tumour suppressor fat and reveal a neuroprotective role of the conserved Fat/Hippo pathway

Topics: Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:3049215
Provided by: PubMed Central
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